Simple blood test would identify key biomarkers
Because early detection of autism is linked to significantly improved outcomes, the discovery of early predictors could make all the difference in a child’s development.
Dr. Ray Bahado-Singh, a geneticist and Chair of Obstetrics and Gynecology for Beaumont Health and the Oakland University William Beaumont School of Medicine and his research team, identified key biomarkers for predicting autism in newborns.
The preliminary, collaborative study used Artificial Intelligence, a computer-based technology which scans a map of the human genome.
The team’s findings could lead to an accessible, standardized newborn screening tool which uses a simple blood test, Dr. Bahado-Singh said, enabling earlier intervention, reducing disability and improving outcomes.
The project compared DNA from 14 known cases of autism to 10 control cases and featured researchers from the Oakland University William Beaumont School of Medicine, Albion College and the University of Nebraska Medical Center.
Results appeared in the journal Brain Research.
“Compared to what is currently available, these findings provide a more direct method which could be employed earlier on, shortly after birth,” Dr. Bahado-Singh said. “It’s been shown that children who are treated earlier do better in life.”
Symptoms of autism include sensory processing difficulties, anxiety, irritability, sleep dysfunction, seizures and gastrointestinal disorders.
According to Autism Speaks, nearly half of 25-year-olds diagnosed with autism have never held a paying job. In the United States, the majority of costs associated with autism are for adult services – an estimated $175 to $196 billion a year, compared to $61 to $66 billion a year for children.
Although the American Academy of Pediatrics recommends all children be screened between 18-24 months, children in large portions of the U.S. do not receive recommended clinical screenings.
“We are always looking for new ways to make a difference in the lives of our patients,” Dr. Warner said. “Getting them into therapy early on is a proven way to make their path, and that of their families, easier and more meaningful.”
Dr. David Aughton, Genetics Chief for Beaumont Children’s, said he looks forward to additional, larger follow-up studies.
“Although it has been thought for many years that the underlying cause of a significant proportion of autism is likely to be nongenetic in nature, this study takes a very pragmatic and important first step toward investigating the epigenome — the inheritable changes in gene expression — and identifying those underlying nongenetic influences. The authors call for larger follow-up studies to validate their findings, and I eagerly look forward to learning the outcome of those validation studies.”